Information about KASPRO

Composition:
 Each Extended-Release Capsule Contains:
-10.24 mg of Metoprolol Free Base, Present as 23.75 mg of Metoprolol Succinate and Equivalent to 25 mg of Metoprolol Tartrate, OR 
- 20.48 mg of Metoprolol Free Base, Present as 47.5 mg of Metoprolol Succinate and Equivalent to 50 mg of Metoprolol Tartrate , OR 
- 40.96 mg of Metoprolol Free Base, Present as 95 mg of Metoprolol Succinate and Equivalent to 100 mg of Metoprolol Tartrate, OR 
- 81.92 mg of Metoprolol Free Base, Present as 190 mg of Metoprolol Succinate and Equivalent to 200 mg of Metoprolol Tartrate.
 Pharmacokinetics:
 Absorption of metoprolol is rapid and complete. Plasma levels following oral administration of conventional metoprolol Capsules, however, approximate 50% of levels following intravenous administration, indicating about 50% first-pass metabolism. Metoprolol crosses the blood-brain barrier and has been reported in the CSF in a concentration 78% of the simultaneous plasma concentration. Only a small fraction of the drug (about 12%) is bound to human serum albumin, and metabolized predominantly by CYP2D6. Elimination is mainly by biotransformation in the liver, and the plasma half-life ranges from approximately 3 to 7 hours. Less than 5% of an oral dose of metoprolol is recovered unchanged in the urine; the rest is excreted by the kidneys as metabolites that appear to have no beta-blocking activity. In comparison to conventional metoprolol, the plasma metoprolol levels following administration of METOPROLOL XR are characterized by lower peaks, longer time to peak. 
Indications:
-Hypertension 
-Angina Pectoris
-Heart Failure
Contraindications:
 heart block greater than first degree, cardiogenic shock, de compensated cardiac failure, 
sick sinus syndrome (unless a permanent pacemaker is in place). 
in patients who are hypersensitive to any component of this product. 

Adverse reactions:
 Most adverse effects have been mild and transient. Hypertension and Angina, Tiredness, dizziness, depression, mental confusion, short-term memory, headache, somnolence, nightmares, and insomnia, Shortness of breath, bradycardia, cold extremities, arterial insufficiency, palpitations, congestive heart failure, peripheral edema, syncope, chest pain, and hypotension , Wheezing (bronchospasm) and dyspnea, Diarrhea, nausea, dry mouth, gastric pain, constipation, flatulence, digestive tract disorders, and heartburn, Pruritus, Worsening of psoriasis.Peyronie,s disease, musculoskeletal pain, blurred vision, decreased libido, tinnitus, myocardial infarction, pneumonia, cerebrovascular disorder, syncope, coronary artery disorder, ventricular tachycardia/arrhythmia aggravated. 

Storage conditions:
 Don’t store above 30° C.

Packaging: 
 Carton Pack of 30 Extended release Capsules in 3 blisters each blister contain 10 Extended release capsules for all strengths.